Schlagwörter

• Regenerative biology
• animal models
• live imaging
• sequencing
• single cell
• stem cells
• tissue and organ regeneration

Beschreibung

• Spiny mice (Acomys) regenerate their skin, including hair follicles, and composite tissues containing cartilage, muscles and nerves, in a scar-free manner. In this project, we will identify and characterize novel gene functions that occurred as part of genomic innovations in spiny mice. We will use spatial transcriptomics and single-cell sequencing datasets in a comparative approach with spiny mice and their non-regenerating relatives, house mice (Mus) and gerbils (Meriones), to identify Acomys-specific gene expression patterns activated upon injury. The ultimate aim of the project is to find ways to activate regenerative traits in normally scarring/fibrotic injury models, such as mouse and human skin.

Laufzeit

• 01.03.2023 - 28.02.2027

Ergebniszusammenfassung

• https://cordis.europa.eu/project/id/101073238/results